Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
As we continue to grow and expand globally, we seek a dynamic and experienced Senior Director, Medical Operations and Project Management to lead operational strategy and excellence across Medical Affairs. Reporting to the Head of Medical Excellence, this role will serve as a senior leader responsible for shaping, driving, and overseeing Medical Affairs operations, governance, project management infrastructure, and cross-functional execution. The Senior Director will be instrumental in enabling medical impact through operational leadership, strategic planning, systems enablement, and inspection readiness across the full product lifecycle. This highly visible role will collaborate across internal teams and external partners to deliver compliant, efficient, and scalable solutions that support global medical strategy, launch readiness, and scientific engagement.
Key responsibilities include:
Strategic Operations Leadership
- Lead the design and execution of the operational strategy for Medical Affairs globally.
- Partner with the Head of Medical Excellence and cross-functional leadership to drive alignment with corporate goals and ensure operational readiness for pipeline acceleration and launches.
- Champion continuous innovation in Medical Affairs operations, digital tools, and process optimization.
Medical Affairs Program & Project Management
- Oversee complex, cross-functional programs spanning scientific platforms, congress strategy, HEOR/IEP coordination, external engagement, advisory boards, medical planning and launch operations.
- Develop and maintain governance for Medical Asset Teams (MATs), Medical Affairs Leadership Team (MALT), key evidence generation initiatives and other Medical Affairs led projects.
- Drive prioritization and resourcing of Medical Affairs initiatives in collaboration with strategic and functional stakeholders.
Financial & Vendor Management
- Lead annual Medical Affairs budgeting process and manage operational and programmatic budgets across teams.
- Oversee contracting strategy, vendor performance, and financial reconciliation to ensure effective and compliant external engagements.
- Build long-term partnerships with preferred vendors to enable consistent, quality-driven medical operations support.
Systems, Tools, and Digital Enablement
- Lead digital transformation initiatives to modernize systems supporting Medical Affairs (e.g., Veeva Medical, Datavision, grants management, project dashboards).
- Oversee implementation and governance of digital platforms for insights management, congress planning, and content review.
- Align data analytics and reporting tools to support evidence strategy, KPI tracking, and business performance reviews.
Organizational Enablement & Leadership
- Provide strategic leadership to a high-performing operations and project management team; oversee hiring, coaching, and professional development.
- Serve as a key advisor and operations partner to therapeutic area leaders, Field Medical, Medical Communications, HEOR, and Clinical Development.
- Establish and maintain SOPs, training, and internal education to build operational excellence and capabilities across Medical Affairs.
Required Skills, Experience and Education:
- Advanced degree required (PharmD, PhD, MBA, or equivalent in life sciences or business); PMP certification strongly preferred.
- Minimum 15+ years (with MBA/Master’s) or 13+ years (with PharmD/PhD) of progressive experience in biotech/pharma, with 8+ years in Medical Affairs operations, project management, or governance roles.
- Proven leadership in managing global Medical Affairs initiatives including launch operations, governance, compliance, congresses, and external engagement.
- Expertise in operational oversight of vendor contracts, budgets, audits, and inspections.
- Deep understanding of industry regulations (FDA, EMA, GxP, ICH, Sunshine Act, PhRMA, ACCME) and medical compliance standards.
- Demonstrated success implementing digital solutions and project governance frameworks within a matrixed environment.
- Strong financial acumen, strategic thinking, and ability to manage ambiguity in a fast-paced environment.
- Excellent interpersonal, communication, and influence skills with executive presence.
Preferred Skills:
- Oncology and/or precision medicine experience strongly preferred.
- Previous leadership of Medical Operations frameworks.
- Experience scaling Medical Affairs operations during rapid growth or product launch phases.
- Familiarity with global medical regulations and market access considerations (HTA, HEOR, IEP).
The base salary range for this full-time position is $236,000 to $295,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact privacy@revmed.com .
