Director, Therapeutic Biology

Generate:Biomedicines • Full-time • Somerville, MA, US • 3w ago

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received over $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees.

The Role:

We are seeking to expand the Experimental Therapeutic Biology team by recruiting a talented Director of Therapeutic Biology. The successful candidate will lead a team of scientists and RAs to employ our platform to unlock novel biology to advance our pipeline of therapeutics in oncology and other therapeutic areas . We are searching for a creative and highly motivated individual who is comfortable working in a fast-paced, entrepreneurial environment. The successful candidate will have extensive experience guiding therapeutic research, including leading early- and late-stage preclinical research programs, drafting regulatory filings and translating protein-based therapeutics to the clinic. Deep experience with antibody-drug conjugates (ADCs) is a plus. The candidate should have a sustained record as a strategic thinker and thoughtful and accomplished people leader.

Here's how you will contribute:

Be a thoughtful and creative leader of therapeutic research that includes a growing team of scientists and research associates.
Be a go-to expert in late-stage preclinical research for scientists across Generate.
Be a strategic thought partner in development of therapeutics from ideation of a therapeutic hypotheses through IND filings and phase 1.
Be a cross-functional program lead on fast-paced therapeutic programs
Identify and advance new opportunities, targets, and modalities and be an expert resource to guide BD opportunities.
Be an excellent people-leader within and across teams.

The Ideal Candidate will have:

Ph.D. in Biology, Biochemistry, Cancer Biology, Immunology or related field with 10+ years of experience conceptualizing and leading therapeutic research projects
Proven scientific leadership on global therapeutic product teams required.
Extended track record of being an outstanding leader and collaborator, a creative problem-solver, and a role model for your reports and colleagues.
Proven direct support of multiple IND and early Phase 1 stage therapeutics.
Deep knowledge of preclinical studies required for regulatory filings and clinical translation.
Strong experience with protein-based immunotherapies, preclinical cancer models, immunological techniques, cell biology and signal transduction pathways
Experience in and a passion for drug discovery in oncology and at least one other therapeutic area.
Antibody-drug conjugate (ADC) experience is a plus
Deep interest in translating our Machine Learning platform into medicines, including having a digital mindset and an ability to adapt to emerging technologies.
Ability to balance multiple projects and modalities and guide the growing portfolio
Growth mindset and desire to work in a fast-paced dynamic environment
Familiarity with computational and/or protein engineering techniques a plus

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster. The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. The Company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.