Sr. Scientist, In Vivo Pharmacology

About Torque Bio:

Torque Bio, Inc. is an ambitious, dynamic biotechnology start-up leveraging the power of innovative technology for the treatment of disease. We believe our science represents a novel class of versatile, tunable, and persistent therapeutics that has the potential to transform the development of new medicines. We are currently seeking talented and passionate individuals that want to join a high-performing team committed to ambitious goal setting and measurable achievement, strong cross-functional collaboration, trust and integrity, collective accountability, and fundamentally meaningful work.

Position Description:

Torque Bio is seeking an enthusiastic and highly motivated Sr. Scientist to work with a cross-functional team. This individual will have extensive experience working with Adeno-Associated Virus (AAV) vectors, as well as a strong background in molecular biology techniques. The Senior Scientist will play a key role in advancing our preclinical research programs and will collaborate closely with internal teams as well as Contract Research Organizations (CROs).

Responsibilities:

Design, plan, and execute in vivo studies utilizing AAV vectors for gene therapy applications.
Manage external CROs, ensuring high-quality data generation and adherence to project timelines, including traveling to monitor outsourced study activities
Review and approve study protocols, protocol amendments, and study reports to ensure compliance with regulatory guidelines, internal standards, and scientific rigor.
Develop, optimize, and perform molecular biology techniques including digital PCR, reverse transcription digital PCR, DNA/RNA extraction, protein assays, Western blots, and ELISAs for use in preclinical studies.
Analyze and interpret experimental data, prepare technical reports, and present findings to cross-functional teams and senior management.
Collaborate closely with cross-functional teams to ensure alignment of study objectives and adherence to project timelines.
Coordinate the procurement, distribution, and analysis of test articles (e.g., AAV vectors, experimental compounds) for in vivo studies, including liaising with external vendors and managing inventory levels.
Serve as a subject matter expert on in vivo study design and execution, and act as a primary point of contact for internal and external stakeholders regarding in vivo study-related inquiries.
Participate in regulatory submissions, providing scientific expertise and supporting documentation as needed.
Contribute to continuous process improvement initiatives aimed at enhancing the efficiency and quality of in vivo research operations.
Stay abreast of relevant scientific literature and emerging technologies in the field of gene therapy and molecular biology.

Basic Qualifications:

Ph.D. or equivalent degree in molecular biology, genetics, biochemistry, or related field.
Minimum of 4 years of industry experience in a research environment, preferably within the biotechnology or pharmaceutical industry.
Demonstrated expertise in working with AAV vectors and conducting in vivo studies, including knowledge of vector design, production, and administration routes.
Experience managing external collaborations with CROs or academic partners is required.
Proficiency in a wide range of molecular biology techniques.
Experience qualifying or validating bioanalytical assays relevant to AAV and working knowledge of bioanalytical method validation guidelines is preferred.
Strong analytical and problem-solving skills, with the ability to troubleshoot experimental issues and propose innovative solutions.
Excellent communication and interpersonal skills, with the ability to collaborate effectively within a multidisciplinary team environment.
Strong collaborative instinct with good time and resource management skills.
Detail oriented, self-motivated, and excited to take on new challenges!

Location:

Torque Bio is located in RTP at 8 Davis Dr, Durham, NC, 27709

Compensation:

Salary: A reasonable estimate of the base salary range for these full-time positions is $101,300- $126,626 (Sr. Scientist). Our salary ranges are determined by role, level, and location. The range(s) displayed on this job posting reflects the minimum and maximum target for new hire salaries across all locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education and training. At Torque Bio, it is not typical for an individual to be hired at or near the top of the range for their role and compensation decisions are dependent on the facts and circumstances of each case.
Bonus
Equity ownership

Benefits:

Medical
Dental
Vision
Long-term disability
Short-term disability
Basic life insurance

Additional Information:

Applicants must be currently authorized to work in the U.S. on a full-time basis.
Torque Bio will not sponsor applicants for work visas.
Torque Bio is an equal opportunity employer. As such, Torque Bio makes hiring and employment decisions without unlawful discrimination on the bases of race, color, sex, gender, gender identity or expression, age (40+ or as otherwise protected by applicable law), religion, national origin, citizenship status, disability, medical condition, genetic information, marital status, sexual orientation, U.S. military or veteran status, or other legally protected status.

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Sr. Scientist, In Vivo Pharmacology